Debreceni Egyetem Szerzői jogi szabályzat és publikációs irányelvek

DE Szerzői jogi szabályzat és publikációs irányelvek rendelkezik az egyetem égisze alatt keletkezett publikációk betöltéséről a Tudóstéren. Az egyetemi tudásvagyont ezen irányelvek és szabályozásoknak megfelelően disszeminálja a DEENK

Molecular hydrogen affords neuroprotection in a new translational piglet model of hypoxic-ischemic encephalopathy

Summary Perinatal asphyxia (PA) is one of the leading causes of neonatal mortality and morbidity worldwide. Despite the adequate neonatal resuscitation techniques, hypoxic-ischemic encephalopathy (HIE) may develop in survivors. Controlled therapeutic hypothermia (TH) became the gold standard care of asphyxiated babies, but its efficacy to prevent long-term disabilities is limited, therefore, additional neuroprotective interventions are required urgently. The newborn pig is regarded as one of the best models for human PA/HIE pathology and testing putative therapeutic interventions. The best methodology to elicit pathophysiologically/clinically relevant PA insult in animals is still being debated perhaps resulting in some of the failures of alleged neuroprotective therapies in clinical trials. Our major aim was to create a translationally relevant newborn piglet PA/HIE model. Accordingly, we investigated the effects of bilateral carotid artery occlusion (BCAO) on cortical blood flow (CoBF), a routinely applied method in the literature to augment hypoxic stress. Then we developed and extensively characterized our new PA/HIE model of PA/HIE and subsequently tested the neuroprotective potential of molecular H2 in our model. Newborn piglets were anesthetized, instrumented and mechanically ventilated. The effects of BCAO on CoBF were analysed through an implanted cranial window by laser speckle contrast imaging and analysis. PA (6%O2, 20%CO2, 20min) was induced in separate groups of animals to elicit HIE. One group served for testing the effects of H2 administered during reventilation (2.1%H2, 21%O2, 4h) on brain electrical activity, neuronal damage and oxidative stress at 24h survival). BCAO did not reduce CoBF. PA elicited clinically relevant severe alterations in cardiovascular and blood gas/metabolic parameters, resulting in depressed electroencephalogram (EEG), extensive neuronal damage associated with oxidative stress assessed by 8-OHdG immunoreactivity. Molecular H2 facilitated EEG recovery, ameliorated neonatal brain injury and alleviated oxidative stress. In conclusion, our new PA method was able to elicit reproducible, moderate/severe HIE without BCAO. The model was adequate to reveal the neuroprotective effect of molecular H2 administered in a clinically relevant, post-insult time window. The mechanism of neuroprotection appears to involve the reduction of oxidative stress. Encouraged by these promising results, to describe the effect of H2 administration combined with TH remains our future direction

A Magyar Katonai- Katasztrófaorvostani Társaság megalakításának előzménye, körülményei. A Magyar Néphadsereg Orvosi Tudományi Tanácsa (MN OTT)

A katonaorvostan csak a XX. század eleje óta önálló szakága az orvostudománynak, de a háborúk tapasztalatainak feldolgozása, a mindennapok orvoslásában való alkalmazása, már az ókori háborúk óta folyamatos és természetes. A Magyar Honvédség a megszületése pillanatától kiemelt figyelmet fordított arra, hogy a tudományos élet részese legyen és hozzájáruljon a magyar egészségügy fejlődéséhez, elismertségéhez. A különböző elnevezésű szerveződések, tudományos fórumok, egyesületek és társaságok mindegyike ezt a célt szolgálta. A jelenlegi Magyar Katonai- Katasztrófaorvostani Társaság példás, tiszteletreméltó és gazdag történelmi múlttal rendelkezik, amelyet működő tudományos társaság immáron 30. évfordulóján megtisztelő és kötelező feladat feleleveníteni. = Although military medicine became an independent branch of medicine only in the early 20th century, analysis of the experiences of wars and their routine implementation in treatment is a continuous and natural practice since ancient wars. From the moment of it’s birth, the Hungarian Defence Forces paid special attention to being part of the scientific life and to contribute to development and recognition of Hungarian healthcare. Organizations, scientific forums, associations and societies under different names all served this purpose. ~e Hungarian Society of Military and Disaster Medicine in it’s present form has an exemplary, respectable and rich history. Reviewing these events on the occasion of the 30th anniversary of the current scientific society is an honorable and obligatory task